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Article

Poly(ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein.

Cellular & molecular biology letters - 1 Jan 2001

Wesierska-Gadek J, Schmid G

Abstract excerpt

We investigated the interaction between poly(ADP-ribose) polymerase-1 (PARP-1) and the product of the tumor suppressor gene p53 using two different approaches. In the first approach, we used primary and immortalized cells derived from wt and PARP-1 -/- mice. We examined whether PARP-1 deficiency would affect the expression of the wild-type (wt) p53 protein. The inactivation of the PARP-1 gene markedly affected...

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PMID: 11544635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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