Article
Regulation of the level of the oncoprotein p53 in non-transformed and transformed cells.
Oncogene - 1 Jan 1990
Reihsaus E, Kohler M, Kraiss S, Oren M, Montenarh M
Abstract excerpt
In order to contribute to the understanding of the activation of the oncoprotein p53 we determined the metabolic stability of p53 in a variety of non-transformed, immortalized and SV40- and non-SV40-transformed cell lines. In addition, we analyzed the metabolic stability of the SV40 large T antig...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Cell Transformation, Neoplastic
- Mice
- Mice, Inbred BALB C
- Oncogene Proteins
- Phenotype
- Phosphoproteins
- Precipitin Tests
- Rats
- Simian virus 40
- Tumor Suppressor Protein p53