Article
Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells.
The Journal of clinical investigation - 1 Oct 1996
Fais F, Sellars B, Ghiotto F, Yan X J, Dono M, Allen S L, Budman D, Dittmar K, Kolitz J, Lichtman S M, Schulman P, Schuster M, Vinciguerra V P, Rai K, Stevenson F K, Gregersen P K, Ferrarini M, Chiorazzi N
Abstract excerpt
Chronic lymphocytic leukemia (CLL) usually involves the expansion of a clone of CD5+ B cells synthesizing IgM antibodies. These B cells appear to be blocked at the antigen receptor-expressing stage of B cell differentiation and are thought not to undergo an isotype class switch to IgG or IgA production. In vivo and in vitro studies suggest, however, that in some instances terminal differentiation and isotype...
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