Article
Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia.
Blood - 1 Nov 1992
Friedman D F, Moore J S, Erikson J, Manz J, Goldman J, Nowell P C, Silberstein L E
Abstract excerpt
Chronic lymphocytic leukemia of B-cell origin (B-CLL) is generally thought to arise by neoplastic transformation of B lymphocytes, which express CD5 and have features of an early stage of B-cell differentiation. To study isotype-switched B-CLL as a potentially more differentiated variant, we perf...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Southern
- Cardiolipins
- Cloning, Molecular
- DNA, Neoplasm
- Enzyme-Linked Immunosorbent Assay
- Genes, Immunoglobulin
- Genetic Variation
- Humans
- Hybridomas
- Immunoglobulin A
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Leukemia, Lymphocytic, Chronic, B-Cell
- Molecular Sequence Data
- Monocytes
- Oligodeoxyribonucleotides