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Article

Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia.

Blood - 1 Nov 1992

Friedman D F, Moore J S, Erikson J, Manz J, Goldman J, Nowell P C, Silberstein L E

Abstract excerpt

Chronic lymphocytic leukemia of B-cell origin (B-CLL) is generally thought to arise by neoplastic transformation of B lymphocytes, which express CD5 and have features of an early stage of B-cell differentiation. To study isotype-switched B-CLL as a potentially more differentiated variant, we performed genetic and functional immunoglobulin (Ig) gene analysis in two cases of CD5+ B-CLL in which the peripheral blood...

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PMID: 1421400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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