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Article

Lack of allelic exclusion and isotype switching in B cell chronic lymphocytic leukemia.

American journal of hematology - 1 Dec 2001

Katayama Y, Sakai A, Katsutani S, Takimoto Y, Kimura A

Abstract excerpt

Two rearranged bands of the IgH gene were detected in a case with B cell chronic lymphocytic leukemia (B-CLL). The expressed VH gene was only VH1 with no somatic mutations in IgM and IgD. The expressions of C mu, C delta, and C gamma were detected by reverse transcription of RNA followed by the polymerase chain reaction (RT-PCR). Sequence analysis of the CDR3 regions of each PCR reaction product showed that the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytogenetic Analysis

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 11754422
DOI: 10.1002/ajh.10042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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