Article
Do CLL B cells correspond to naive or memory B-lymphocytes? Evidence for an active Ig switch unrelated to phenotype expression and Ig mutational pattern in B-CLL cells.
Leukemia - 1 Dec 2002
Oppezzo P, Magnac C, Bianchi S, Vuillier F, Tiscornia A, Dumas G, Payelle-Brogard B, Ajchenbaum-Cymbalista F, Dighiero G, Pritsch O
Abstract excerpt
Recent work suggests that chronic lymphocytic leukemia (B-CLL) expressing unmutated immunoglobulin V genes could correspond to the proliferation of naive B cells whereas those expressing mutated genes, may correspond to the proliferation of post-germinal center B cells. Current data from gene profiling expression have failed to demonstrate a clear-cut distinction between these two forms of B-CLL disease. In the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.