Article
Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2002
Cerutti Andrea, Zan Hong, Kim Edmund C, Shah Shefali, Schattner Elaine J, Schaffer András, Casali Paolo
Abstract excerpt
Chronic lymphocytic leukemia (CLL) results from the expansion of malignant CD5(+) B cells that usually express IgD and IgM. These leukemic cells can give rise in vivo to clonally related IgG(+) or IgA(+) elements. The requirements and modalities of this process remain elusive. Here we show that leukemic B cells from 14 of 20 CLLs contain the hallmarks of ongoing Ig class switch DNA recombination (CSR), including...
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