Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations.

The Journal of clinical investigation - 15 Jul 1996

Efremov D G, Ivanovski M, Batista F D, Pozzato G, Burrone O R

Abstract excerpt

The malignant B cells in chronic lymphocytic leukemia (CLL) typically express low-density membrane IgM or IgM/IgD. In vitro experiments have shown that the CLL cells can be induced to differentiate into cells that secrete immunoglobulin (Ig) and can occasionally undergo heavy (H) chain class switching. We now show that the CLL cells also undergo isotype-switching in vivo, since gamma and/or alpha H chain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA Fingerprinting

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Genes, Immunoglobulin

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 8755637
DOI: 10.1172/JCI118792
PMCID: PMC507430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations.PMID 8755637Read ↗

Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells.Semantic proximity Read ↗

Do CLL B cells correspond to naive or memory B-lymphocytes? Evidence for an active Ig switch unrelated to phenotype expression and Ig mutational pattern in B-CLL cells.Semantic proximity Read ↗

Lack of allelic exclusion and isotype switching in B cell chronic lymphocytic leukemia.Semantic proximity Read ↗

Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells.Semantic proximity Read ↗

Evidence for a Large Compartment of IgM-Expressing Memory B Cells in HumansSemantic proximity Read ↗

IgG-secreting lymphoplasmacytoid leukaemia: a B-cell disorder with extensively mutated VH genes undergoing Ig isotype-switching frequently associated with trisomy 12.Semantic proximity Read ↗

Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells.Semantic proximity Read ↗

Molecular comparison of cultured hybridoma cells that switch isotypes at high and low rates.Semantic proximity Read ↗

Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia.Semantic proximity Read ↗

Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life.Semantic proximity Read ↗

Human splenic IgM immunoglobulin transcripts are mutated at high frequency.Semantic proximity Read ↗

Immunoglobulin class-switch recombination occurs in mantle cell lymphomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.