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Article

Isotype switch variants reveal clonally related subpopulations in diffuse large B-cell lymphoma.

Blood - 1 Oct 2000

Ottensmeier C H, Stevenson F K

Abstract excerpt

Primary diffuse large B-cell lymphomas (DLBCLs) are aggressive tumors accounting for approximately 40% of B-cell malignancies. The immunoglobulin (Ig) variable region genes have undergone rearrangement and are commonly somatically mutated. The majority show intraclonal variation which indicates that somatic mutation has continued after transformation. Typically, cells of DLBCLs express Ig of a single isotype, but...

Topics

Adult
Aged
Amino Acid Sequence
Base Sequence
Female
Flow Cytometry
Gene Rearrangement, B-Lymphocyte
Humans
Immunoglobulin A
Immunoglobulin D
Immunoglobulin G
Immunoglobulin Isotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin M

Immunoglobulin Variable Region

Immunohistochemistry

Lymphoma, B-Cell

Lymphoma, Large B-Cell, Diffuse

Male

Source

Identifiers

PMID: 11001910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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