Article
Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.
The Journal of clinical investigation - 15 Oct 1998
Fais F, Ghiotto F, Hashimoto S, Sellars B, Valetto A, Allen S L, Schulman P, Vinciguerra V P, Rai K, Rassenti L Z, Kipps T J, Dighiero G, Schroeder H W, Ferrarini M, Chiorazzi N
Abstract excerpt
To better understand the stage(s) of differentiation reached by B-type chronic lymphocytic leukemia (B-CLL) cells and to gain insight into the potential role of antigenic stimulation in the development and diversification of these cells, we analyzed the rearranged VH genes expressed by 83 B-CLL cells (64 IgM+ and 19 non-IgM+). Our results confirm and extend the observations of a bias in the use of certain VH, D,...
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