Article
CYP2C19 genetic mutations in North Indians.
Clinical pharmacology and therapeutics - 1 Sept 2000
Lamba J K, Dhiman R K, Kohli K K
Abstract excerpt
OBJECTIVES: To identify defective alleles of CYP2C19 (CYP2C19*2 and *3) in North Indians. METHODS: One hundred extensive metabolizers and 21 poor metabolizers of omeprazole were genotyped with respect to CYP2C19*2 and *3 alleles with polymerase chain reaction-based diagnostic tests. RESULTS: Fifty-two extensive metabolizers and six poor metabolizers were homozygous with the CYP2C19*1/*1 genotype, and 48 extensive...
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