Article
Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype.
Pharmacogenetics - 1 Dec 1995
Chang M, Dahl M L, Tybring G, Götharson E, Bertilsson L
Abstract excerpt
A single oral dose of omeprazole (20 mg) was given orally to 160 healthy Caucasian Swedish subjects and tested as a probe for CYP2C19. The study was nonrandomized and included seven subjects previously classified as poor metabolizers (PM) of S-mephenytoin. The ratio between the plasma concentrati...
Topics
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Adult
- Alleles
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Female
- Genotype
- Humans
- Hydroxylation
- Male
- Mephenytoin