Article
Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker.
Clinical pharmacology and therapeutics - 1 Aug 2002
Kim Myong-Jin, Bertino Joseph S, Gaedigk Andrea, Zhang Yanhua, Sellers Edward M, Nafziger Anne N
Abstract excerpt
BACKGROUND: Literature addressing the effect of sex on cytochrome P450 (CYP) 2C19 activity is conflicting. The exogenous female sex steroid hormones used in oral contraceptives are believed to significantly inhibit CYP2C19 activity. However, the effect of variations in endogenous sex steroid concentrations throughout the menstrual cycle has not been investigated. OBJECTIVE: The objective of this study was to...
Topics
- Adult
- Aryl Hydrocarbon Hydroxylases
- Biomarkers
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Female
- Follicular Phase
- Genotype
- Humans
- Luteal Phase
- Male
- Menstrual Cycle
- Middle Aged
- Mixed Function Oxygenases
- Omeprazole
- Phenotype
- Reference Values
- Sex Factors