Article
CYP2D6 genotyping in a Russian population using a novel approach for identification of the CYP2D6A mutation.
Biochemical and molecular medicine - 1 Aug 1996
Akhmedova S N, Pushnova E A, Anisimov S, Bogdanova L A, Bova L K, Schwartz E I
Abstract excerpt
The frequency of 29A and 29B mutations in the CYP2D6 gene, the most common mutations among Caucasoid PM (debrisoquine 4-hydroxylase defficient) individuals, has been analyzed in the Russian population. For the detection of the 29A mutation, a new one-step ARMS PCR approach has been developed. The frequency of the 29B mutant allele in Russians appeared to be significantly lower than in other Caucasoid populations,...
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