Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene.

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Article

Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene.

Pharmacogenetics - 1 Jun 1993

Broly F, Meyer U A

Abstract excerpt

A mutant allele of the CYP2D6 gene (CYP2D6* C) characterized by a 3-base-pair deletion in exon 5 (mutation D6-C) and carried by a Xba I 29 kb restriction fragment (haplotype 29-C) was previously presumed to be associated with the debrisoquine poor metabolizer phenotype on the basis of in vitro en...

Topics

Adult
Base Sequence
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
DNA
Debrisoquin
Exons
Female
Genetic Carrier Screening
Humans
Male
Middle Aged
Mixed Function Oxygenases
Molecular Sequence Data
Mutation
Oxidation-Reduction
Pedigree
Phenotype

Source

Open in PubMed

Identifiers

PMID: 8101460

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8101460-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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