Frequency of human CYP2D6 mutant alleles in a normal Chinese population.

doi:10.1111/j.1365-2125.1994.tb04311.x

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Article

Frequency of human CYP2D6 mutant alleles in a normal Chinese population.

British journal of clinical pharmacology - 1 Jun 1994

Lee E J, Jeyaseelan K

Abstract excerpt

Substantial differences in the pharmacogenetics of debrisoquine hydroxylation exist between Caucasians and Chinese populations. Among Chinese, not only is the frequency of the poor metabolizer phenotype low, the contribution of the 29B mutation in the CYP2D6 gene is insignificant. By contrast the...

Topics

Adult
Alleles
China
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Female
Humans
Male
Mixed Function Oxygenases
Mutation
Reference Values

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