Article
Frequency of human CYP2D6 mutant alleles in a normal Chinese population.
British journal of clinical pharmacology - 1 Jun 1994
Lee E J, Jeyaseelan K
Abstract excerpt
Substantial differences in the pharmacogenetics of debrisoquine hydroxylation exist between Caucasians and Chinese populations. Among Chinese, not only is the frequency of the poor metabolizer phenotype low, the contribution of the 29B mutation in the CYP2D6 gene is insignificant. By contrast the frequency of D6-J is very common (approximately 0.6) and is clearly related to the activity of debrisoquine...
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