Article
Debrisoquine and S-mephenytoin hydroxylation polymorphisms in a Russian population living in Estonia.
European journal of clinical pharmacology - 1 Jan 1997
Marandi T, Dahl M L, Rägo L, Kiivet R, Sjöqvist F
Abstract excerpt
OBJECTIVE: To investigate the CYP2D6 and CYP2C19 phenotypes and genotypes in a Russian population of Estonia. METHODS: Two hundred and eighteen unrelated healthy subjects of Russian origin were studied. All participants took 10 mg debrisoquine and 100 mg S/R-mephenytoin for phenotyping. The CYP2D6 genotype was analysed by PCR amplification for the CYP2D6*3 and CYP2D6*4 alleles and subjects with S/R-mephenytoin...
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