Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population.

doi:10.1016/0009-9236(95)90151-5

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Article

Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population.

Clinical pharmacology and therapeutics - 1 Mar 1995

Agúndez J A, Ledesma M C, Ladero J M, Benítez J

Abstract excerpt

The occurrence of multiple copies of the CYP2D6 gene was investigated 217 white healthy Spaniards by the combined use of Xba I and Eco RI restriction fragment length polymorphism (RFLP) analyses. About 3.5% of the alleles yielded an 12.1 kb Eco RI-RFLP product in combination with the 42 kb Xba I-RFLP product, which is indicative of multiple CYP2D6. The prevalence of subjects carrying multiple CYP2D6 was 7%. The...

Topics

Adult
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Debrisoquin
Female
Humans
Male
Middle Aged
Mixed Function Oxygenases
Multigene Family
Oxidation-Reduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymorphism, Restriction Fragment Length

Prevalence

Reference Values

Spain

White People

Source

Open in PubMed

Identifiers

PMID: 7697944
DOI: 10.1016/0009-9236(95)90151-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7697944-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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