Article
Characterization of the CYP2D6*29 allele commonly present in a black Tanzanian population causing reduced catalytic activity.
Pharmacogenetics - 1 Jul 2001
Wennerholm A, Johansson I, Hidestrand M, Bertilsson L, Gustafsson L L, Ingelman-Sundberg M
Abstract excerpt
Debrisoquine metabolism among Tanzanians has been found to be slower than expected from the CYP2D6 genotype. In order to evaluate any genetic explanation, the coding sequence and intron-exon boundaries of the CYP2D6 gene from three Black Tanzanian volunteers with a CYP2D6*1/*1 or CYP2D6*2/*2 genotype and debrisoquine metabolic ratios (MRs) > 1 were fully sequenced to screen for new mutations. Two functional...
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