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Article

Ultrarapid metabolizers of debrisoquine: characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene.

FEBS letters - 19 Aug 1996

Løvlie R, Daly A K, Molven A, Idle J R, Steen V M

Abstract excerpt

Up to 7% of Caucasians may demonstrate ultrarapid metabolism of debrisoquine due to inheritance of alleles with duplicated functional CYP2D6 genes. Here we describe the genomic organization of the duplicated CYP2D6 genes in the 42 kb XbaI allele. We postulate that this duplication originates from...

Topics

Alleles
Base Sequence
Crossing Over, Genetic
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
DNA
Debrisoquin
Humans
Mixed Function Oxygenases
Molecular Sequence Data
Multigene Family
Polymerase Chain Reaction

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Identifiers

PMID: 8769309
DOI: 10.1016/0014-5793(96)00779-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8769309-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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