Article
High prevalence of CYP2D6*41 (G2988A) allele in Saudi Arabians.
Environmental toxicology and pharmacology - 1 Nov 2013
Al-Dosari Mohammed S, Al-Jenoobi Fahad I, Alkharfy Khalid M, Alghamdi Amal M, Bagulb Khawla M, Parvez Mohammad K, Al-Mohizea Abdullah M, Al-Muhsen Saleh, Halwani Rabih
Abstract excerpt
The main objective of this study was to evaluate CYP2D6 genetic polymorphism in a Saudi Arabian population by determining the frequencies of CYP2D6*41, CYP2D6*29, CYP2D6*3, CYP2D6*6 and CYP2D6*14 alleles. Genomic DNA was isolated from 192 healthy Saudis representing different geographical regions, and genotyping of the selected CYP2D6 variants was carried out by direct sequencing. The allelic frequency of...
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