Article
Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes.
Pharmacogenetics - 1 Oct 1991
Daly A K, Armstrong M, Monkman S C, Idle M E, Idle J R
Abstract excerpt
A randomly selected population of 73 volunteers, together with 22 previously established poor metabolisers of debrisoquine, were phenotyped for their ability to 4-hydroxylate debrisoquine and were also analysed for a number of mutations in the CYP2D6 gene. Genotyping was performed using both rest...
Topics
- Alleles
- Base Sequence
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA
- Debrisoquin
- Deoxyribonucleases, Type II Site-Specific
- Exons
- Female
- Genotype
- Homozygote
- Humans
- Leukocytes
- Male
- Mixed Function Oxygenases
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides