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Directed evolution of estrogen receptor proteins with altered ligand-binding specificities.

Protein engineering, design & selection : PEDS - 1 Jan 2009

Islam Kazi Mohammed Didarul, Dilcher Meik, Thurow Corinna, Vock Carsten, Krimmelbein Ilga Kristine, Tietze Lutz Friedjan, Gonzalez Victor, Zhao Huimin, Gatz Christiane

Abstract excerpt

Transcriptional activators that respond to ligands with no cellular targets are powerful tools that can confer regulated expression of a transgene in almost all biological systems. In this study, we altered the ligand-binding specificity of the human estrogen receptor alpha (hER alpha) so that it would recognize a non-steroidal synthetic compound with structural similarities to the phytoestrogen resveratrol. For...

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PMID: 19088113
DOI: 10.1093/protein/gzn067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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