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Article

Directed evolution of human estrogen receptor variants with significantly enhanced androgen specificity and affinity.

The Journal of biological chemistry - 6 Aug 2004

Chen Zhilei, Katzenellenbogen Benita S, Katzenellenbogen John A, Zhao Huimin

Abstract excerpt

Human estrogen receptor alpha (hERalpha) and human androgen receptor exhibit exquisite ligand specificity, which underlies their remarkable ability to effect ligand-regulated gene transcription in a highly distinctive and specific manner. Here we used a directed evolution approach to create hERalpha variants with enhanced androgen specificity and affinity with the goal to better understand the molecular basis of...

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Source

Identifiers

PMID: 15159406
DOI: 10.1074/jbc.M402118200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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