Article
Polymorphisms in the human apolipoprotein-J/clusterin gene: ethnic variation and distribution in Alzheimer's disease.
Human genetics - 1 Oct 1996
Tycko B, Feng L, Nguyen L, Francis A, Hays A, Chung W Y, Tang M X, Stern Y, Sahota A, Hendrie H, Mayeux R
Abstract excerpt
Apolipoprotein-J/clusterin (APOJ/CLI) shares many biological properties with apolipoprotein-E (APOE) including, but not limited to, avid binding with beta-amyloid peptide. Thus, APOJ/CLI warrants scrutiny as a candidate Alzheimer's disease (AD) susceptibility gene. We identified seven nucleotide sequence polymorphisms in APOJ/ CLI, two of which, in exon 7, after the predicted amino acid sequence. The JVIIB...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
