Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain clusterin protein isoforms and mitochondrial localization

18 Nov 2019

Abstract excerpt

Clusterin (CLU), or apolipoprotein J (ApoJ), is the third most predominant genetic risk factor associated with late-onset Alzheimer’s disease (LOAD). In this study, we use multiple rodent and human brain tissue and neural cell models to demonstrate that CLU is expressed as multiple isoforms that have distinct cellular or subcellular localizations in the brain. Of particular significance, we identify a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clusterin in disease pathology
Share to Mitochondrial Function and Pathology

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 31738162
DOI: 10.7554/elife.48255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain clusterin protein isoforms and mitochondrial localizationPMID 31738162Read ↗

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other PathologiesSemantic proximity Read ↗

Genetics of clusterin isoform expression and Alzheimer's disease risk.Semantic proximity Read ↗

The Role of Clusterin in Alzheimer’s Disease: Pathways, Pathogenesis, and TherapySemantic proximity Read ↗

Single Nucleotide Polymorphism rs11136000 of CLU Gene (Clusterin, ApoJ) and the Risk of Late-Onset Alzheimer's Disease in a Central European Population.Semantic proximity Read ↗

Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's DiseaseSemantic proximity Read ↗

Genetic variation in clusterin gene and Alzheimer's disease risk in Han Chinese.Semantic proximity Read ↗

Clusterin levels are increased in <scp>A</scp>lzheimer's disease and influence the regional distribution of A<b>β</b>Semantic proximity Read ↗

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.Semantic proximity Read ↗

Non-Secreted Clusterin Isoforms Are Translated in Rare Amounts from Distinct Human mRNA Variants and Do Not Affect Bax-Mediated Apoptosis or the NF-κB Signaling PathwaySemantic proximity Read ↗

Clusterin as a Potential Biomarker of Obesity-Related Alzheimer’s Disease RiskSemantic proximity Read ↗

<i>TOMM40</i> suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer’s diseaseSemantic proximity Read ↗

Glycosylated clusterin species facilitate Aβ toxicity in human neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.