Article
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
Nature genetics - 1 Oct 2009
Lambert Jean-Charles, Heath Simon, Even Gael, Campion Dominique, Sleegers Kristel, Hiltunen Mikko, Combarros Onofre, Zelenika Diana, Bullido Maria J, Tavernier Béatrice, Letenneur Luc, Bettens Karolien, Berr Claudine, Pasquier Florence, Fiévet Nathalie, Barberger-Gateau Pascale, Engelborghs Sebastiaan, De Deyn Peter, Mateo Ignacio, Franck Ana, Helisalmi Seppo, Porcellini Elisa, Hanon Olivier, de Pancorbo Marian M, Lendon Corinne, Dufouil Carole, Jaillard Céline, Leveillard Thierry, Alvarez Victoria, Bosco Paolo, Mancuso Michelangelo, Panza Francesco, Nacmias Benedetta, Bossù Paola, Piccardi Paola, Annoni Giorgio, Seripa Davide, Galimberti Daniela, Hannequin Didier, Licastro Federico, Soininen Hilkka, Ritchie Karen, Blanché Hélène, Dartigues Jean-François, Tzourio Christophe, Gut Ivo, Van Broeckhoven Christine, Alpérovitch Annick, Lathrop Mark, Amouyel Philippe
Abstract excerpt
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wide association study of 2,032 individuals from France with Alzheimer's disease (cases) and 5,328 controls. Markers outside APOE with suggestive evidence of association (P < 10(-5)) were examined in collections from...
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