Article
Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease.
Clinica chimica acta; international journal of clinical chemistry - 9 Oct 2010
Yu Jin-Tai, Li Lu, Zhu Qi-Xiu, Zhang Qun, Zhang Wei, Wu Zhong-Chen, Guan Jun, Tan Lan
Abstract excerpt
BACKGROUND: Clusterin (also called apolipoprotein J) has a potential central role in the pathogenesis of Alzheimer's disease (AD). Recently, two genome-wide association studies have identified three variants in CLU gene encoding clusterin associated with AD risk in Caucasians, while there are no studies on the association of CLU with AD risk in Asians. METHODS: The study investigated 324 sporadic late-onset AD...
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