Article
Genetic variation in clusterin gene and Alzheimer's disease risk in Han Chinese.
Neurobiology of aging - 1 Jul 2013
Yu Jin-Tai, Ma Xiao-Ying, Wang Ying-Li, Sun Lei, Tan Lin, Hu Nan, Tan Lan
Abstract excerpt
Clusterin gene (CLU), also known as apolipoprotein J (ApoJ), is a strong candidate gene for late-onset Alzheimer's disease (LOAD) according to the Alzgene database. To further characterize this association and to isolate the variants contributing to the pathogenesis of LOAD in Han Chinese, we first sequenced a small sample (n = 100) to discover variants in the promoter, exons, the 5' and 3' untranslated regions,...
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