Article
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.
Molecular neurodegeneration - 16 Jan 2012
Bettens Karolien, Brouwers Nathalie, Engelborghs Sebastiaan, Lambert Jean-Charles, Rogaeva Ekaterina, Vandenberghe Rik, Le Bastard Nathalie, Pasquier Florence, Vermeulen Steven, Van Dongen Jasper, Mattheijssens Maria, Peeters Karin, Mayeux Richard, St George-Hyslop Peter, Amouyel Philippe, De Deyn Peter P, Sleegers Kristel, Van Broeckhoven Christine
Abstract excerpt
BACKGROUND: We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all CLU coding exons and regulatory regions in an extended Flanders-Belgian cohort of Caucasian AD patients and control individuals (n = 1930). Moreover, we have replicated genetic findings by targeted resequencing in...
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