Article
Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals.
BMC medicine - 14 Mar 2018
Nordestgaard Liv Tybjærg, Tybjærg-Hansen Anne, Rasmussen Katrine Laura, Nordestgaard Børge G, Frikke-Schmidt Ruth
Abstract excerpt
BACKGROUND: Clusterin, also known as apolipoprotein J (apoJ), is one of the most abundantly expressed apolipoproteins in the brain after apolipoprotein E (apoE). Like the ε4 allele of the apolipoprotein E gene (APOE), the clusterin gene (CLU) is a risk locus for Alzheimer's disease, and may play additional roles in atherosclerosis pathogenesis. We tested whether genetic variation in CLU was associated with either...
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