Article
Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets.
Development (Cambridge, England) - 1 Apr 2000
van Ewijk W, Holländer G, Terhorst C, Wang B
Abstract excerpt
T-cell development is under the tight control of thymic microenvironments. Conversely, the integrity of thymic microenvironments depends on the physical presence of developing thymocytes, a phenomenon designated as 'thymic crosstalk'. We now show, using three types of immunodeficient mice, i.e. CD3(epsilon) transgenic mice, RAG(null) mice and RAG(null)-bone-marrow-transplanted CD3(epsilon) transgenic mice, that...
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