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Article

Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.

PloS one - 1 Jan 2013

Ogawa Masahiro, Okamura Tadashi, Ishikura Shuhei, Doi Keiko, Matsuzaki Hiroshi, Tanaka Yoko, Ota Takeharu, Hayakawa Kunihiro, Suzuki Harumi, Tsunoda Toshiyuki, Sasazuki Takehiko, Shirasawa Senji

Abstract excerpt

The human ZFAT gene was originally identified as a susceptibility gene for autoimmune thyroid disease. Mouse Zfat is a critical transcriptional regulator for primitive hematopoiesis and required for peripheral T cell homeostasis. However, its physiological roles in T cell development remain poorly understood. Here, we generated Zfat (f/f)-LckCre mice and demonstrated that T cell-specific Zfat-deletion in Zfat...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24098453
DOI: 10.1371/journal.pone.0076254
PMCID: PMC3789737

Genes

ZFAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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