Infrequent mutation of p16INK4 in sporadic melanoma.

doi:10.1111/1523-1747.ep12363118

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Article

Infrequent mutation of p16INK4 in sporadic melanoma.

The Journal of investigative dermatology - 1 Sept 1996

Healy E, Sikkink S, Rees J L

Abstract excerpt

Loss of heterozygosity of chromosome region 9p21 occurs commonly and early in sporadic melanoma, suggesting the involvement of a tumor suppressor gene at this locus in the pathogenesis of this neoplasm. Although germline mutations and deletions of the p16INK4 gene located at 9p21 have been report...

Topics

Base Sequence
Chromosomes, Human, Pair 9
Heterozygote
Humans
Melanoma
Molecular Probes
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Skin Neoplasms

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