Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma.

doi:10.1046/j.1365-2133.1998.02020.x

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Article

Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma.

The British journal of dermatology - 1 Jan 1998

Wagner S N, Wagner C, Briedigkeit L, Goos M

Abstract excerpt

Chromosome 9p21 is frequently deleted in malignant melanoma, and one familial malignant melanoma gene has been linked to 9p21-22. Recently, the cyclin D-dependent kinase inhibitors (CDKIs) p16INK4a and p15INK4b have been localized within chromosome 9p21, and the presence of p16INK4a point mutatio...

Topics

Blotting, Southern
Gene Deletion
Gene Expression
Genes, Tumor Suppressor
Genes, p16
Humans
Melanoma
Mutation
Neoplasm Proteins
Polymerase Chain Reaction
RNA, Messenger
RNA, Neoplasm
Sensitivity and Specificity
Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 9536218
DOI: 10.1046/j.1365-2133.1998.02020.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9536218-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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