Article
Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma.
Cancer research - 1 Nov 1996
Flores J F, Walker G J, Glendening J M, Haluska F G, Castresana J S, Rubio M P, Pastorfide G C, Boyer L A, Kao W H, Bulyk M L, Barnhill R L, Hayward N K, Housman D E, Fountain J W
Abstract excerpt
Although homozygous deletions of the cyclin-dependent kinase inhibitor 2 gene p16INK4a on 9p21 have been reported frequently in metastatic melanoma cell lines, and intragenic mutations within the p16INK4a gene have been detected in familial melanoma kindreds, specific targeting of this gene in th...
Topics
- Carrier Proteins
- Cell Cycle Proteins
- Chromosome Deletion
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Gene Deletion
- Genes, Tumor Suppressor
- Genetic Markers
- Humans
- Melanoma
- Mutation
- Tumor Cells, Cultured