Article
Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma.
International journal of cancer - 15 Mar 1996
Ohta M, Berd D, Shimizu M, Nagai H, Cotticelli M-G, Mastrangelo M, Shields J A, Shields C L, Croce C M, Huebner K
Abstract excerpt
The cyclin-dependent kinase-4 inhibitor gene CDKN2, localized at chromosome region 9p21, has been shown to be a familial melanoma gene, though we found that mutations of it are rare in uncultured sporadic melanomas. To determine Whether the region of allelic loss at 9p21 frequently observed in sporadic melanomas includes the CDKN2 locus, new polymorphic microsatellite probes were isolated from the genomic...
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