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Article

Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma.

International journal of cancer - 15 Mar 1996

Ohta M, Berd D, Shimizu M, Nagai H, Cotticelli M-G, Mastrangelo M, Shields J A, Shields C L, Croce C M, Huebner K

Abstract excerpt

The cyclin-dependent kinase-4 inhibitor gene CDKN2, localized at chromosome region 9p21, has been shown to be a familial melanoma gene, though we found that mutations of it are rare in uncultured sporadic melanomas. To determine Whether the region of allelic loss at 9p21 frequently observed in sp...

Topics

Alleles
Base Sequence
Carrier Proteins
Chromosome Mapping
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 9
Cyclin-Dependent Kinase Inhibitor p16
DNA, Neoplasm
Gene Deletion
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Melanoma

Molecular Sequence Data

Skin Neoplasms

Uveal Neoplasms

Source

Identifiers

PMID: 8631588
DOI: 10.1002/(SICI)1097-0215(19960315)65:6<762::AID-IJC9>3.0.CO;2-X

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8631588-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma.PMID 8631588Read ↗

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Prevalence of 9p21 deletions in UK melanoma familiesSemantic proximity Read ↗

Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma.Semantic proximity Read ↗

Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma.Semantic proximity Read ↗

Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds.Semantic proximity Read ↗

Differential allele loss on chromosome 9q22.3 in human non-melanoma skin cancer.Semantic proximity Read ↗

The current situation with regard to human melanoma and genetic inferences.Semantic proximity Read ↗

9p21 deletions in primary melanoma.Semantic proximity Read ↗

Evidence for three tumor suppressor loci on chromosome 9p involved in melanoma development.Semantic proximity Read ↗

Loss of heterozygosity at chromosome 9p21 (INK4-p14ARF locus): homozygous deletions and mutations in the p16 and p14ARF genes in sporadic primary melanomas.Semantic proximity Read ↗

The contribution of large genomic deletions at the CDKN2A locus to the burden of familial melanoma.Semantic proximity Read ↗

Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.Semantic proximity Read ↗

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