Article
Genetic alterations of p16INK4a and p53 genes in sporadic dysplastic nevus.
Biochemical and biophysical research communications - 28 Aug 1997
Lee J Y, Dong S M, Shin M S, Kim S Y, Lee S H, Kang S J, Lee J D, Kim C S, Kim S H, Yoo N J
Abstract excerpt
It is still unclear whether the sporadic form of dysplastic nevi (SDN) represents a premalignant lesion of malignant melanoma and whether genetic alterations are involved in the development of SDN. To determine whether p16INK4a and p53 genetic abnormalities could be associated with development of SDN, nevus cell nests were procured selectively from H & E-stained slide sections by using a modified microdissection...
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