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Article

p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanoma

1 Jul 1998

Abstract excerpt

The product of the p16/INK4a/CDKN2/MTS1 tumor-suppressor gene acts as a negative cell cycle regulator by inhibiting G1 cyclin-dependent kinases that phosphorylate the retinoblastoma protein. p16 is inactivated in a wide range of human malignancies, including familial melanoma. However, its expression and function in sporadic melanoma has not been extensively investigated. We studied p16 expression in 62 archival...

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Identifiers

PMID: 9694617
DOI: 10.1111/j.1600-0560.1998.tb01748.x

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p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanomaPMID 9694617Read ↗

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