Article
Allelotypes of primary cutaneous melanoma and benign melanocytic nevi.
Cancer research - 1 Feb 1996
Healy E, Belgaid C E, Takata M, Vahlquist A, Rehman I, Rigby H, Rees J L
Abstract excerpt
A multistep genetic model of tumorigenesis, based on genetic alterations in benign and primary malignant lesions, has been proposed for neoplasms such as colonic carcinoma. However, evidence for a similar genetic progression in melanoma has relied heavily on findings in cultured lesions or metastases. We have investigated every autosomal arm for loss of heterozygosity in 41 primary cutaneous melanomas and 32...
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