Article
Allelic deletion at chromosome 9p21(p16) and 17p13(p53) in microdissected sporadic dysplastic nevus.
Human pathology - 1 Feb 1998
Park W S, Vortmeyer A O, Pack S, Duray P H, Böni R, Guerami A A, Emmert-Buck M R, Liotta L A, Zhuang Z
Abstract excerpt
A critical area of chromosomal loss at region p16(9p21-22) and p53(17p13) has been implicated in the genesis of malignant melanoma. It is still unclear whether the genetic alterations can be detected in dysplastic nevus, a premalignant lesion of malignant melanoma. We have searched the frequency of p16 and p53 deletion in nine dysplastic nevi and 13 benign intradermal nevi with five microsatellite markers....
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