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Article

p16INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma.

Oncogene - 15 Apr 1999

Fujimoto A, Morita R, Hatta N, Takehara K, Takata M

Abstract excerpt

In an attempt to examine whether the inactivation of p16INK4a is an important early event in the development of sporadic melanoma in vivo, we have systematically analysed 46 uncultured primary cutaneous melanomas. Loss of heterozygosity (LOH) of chromosome region 9p21-22 (where the p16INK4a resides) was detected in 11 tumours (24%) by PCR-based LOH analyses. Direct sequencing of all three exons of the p16INK4a...

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Share to Chromosomes, Human, Pair 9
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10229204
DOI: 10.1038/sj.onc.1202803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p16INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma.PMID 10229204Read ↗

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