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Article

Infrequent mutations of p16INK4A and p15INK4B genes in human pituitary adenomas.

European journal of endocrinology - 1 Jan 1997

Yoshimoto K, Tanaka C, Yamada S, Kimura T, Iwahana H, Sano T, Itakura M

Abstract excerpt

The p16INK4A and p15INK4B genes on chromosome 9p21 encode the p16 and p15 inhibitors of cyclin D/cyclin-dependent kinase 4 complexes respectively. Mutations and deletions of the p16INK4A gene have been found in melanomas and many other types of tumors. To assess the role of the p16INK4A and p15NK4B genes in tumorigenesis of the pituitary gland, 31 sporadic pituitary adenomas and 2 pituitary adenomas in familial...

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Identifiers

PMID: 9037130
DOI: 10.1530/eje.0.1360074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Infrequent mutations of p16INK4A and p15INK4B genes in human pituitary adenomas.PMID 9037130Read ↗

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p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanomaSemantic proximity Read ↗

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Human pituitary adenomas infrequently contain inactivation of retinoblastoma 1 gene and activation of cyclin dependent kinase 4 gene.Semantic proximity Read ↗

Infrequent mutation of p16INK4 in sporadic melanoma.Semantic proximity Read ↗

The p15<sup>INK4b</sup>/p16<sup>INK4a</sup>/RB1 Pathway Is Frequently Deregulated in Human Pituitary AdenomasSemantic proximity Read ↗

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Loss of heterozygosity at chromosome 9p21 (INK4-p14ARF locus): homozygous deletions and mutations in the p16 and p14ARF genes in sporadic primary melanomas.Semantic proximity Read ↗

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