Infrequent mutations of p16INK4A and p15INK4B genes in human pituitary adenomas.

doi:10.1530/eje.0.1360074

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Article

Infrequent mutations of p16INK4A and p15INK4B genes in human pituitary adenomas.

European journal of endocrinology - 1 Jan 1997

Yoshimoto K, Tanaka C, Yamada S, Kimura T, Iwahana H, Sano T, Itakura M

Abstract excerpt

The p16INK4A and p15INK4B genes on chromosome 9p21 encode the p16 and p15 inhibitors of cyclin D/cyclin-dependent kinase 4 complexes respectively. Mutations and deletions of the p16INK4A gene have been found in melanomas and many other types of tumors. To assess the role of the p16INK4A and p15NK...

Topics

Adenoma
Adolescent
Adult
Aged
Base Sequence
Carrier Proteins
Cell Cycle Proteins
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
DNA Primers
Female
Humans
Leukocytes
Male
Microsatellite Repeats
Middle Aged
Mutation
Pituitary Neoplasms

Source

Open in PubMed

Identifiers

PMID: 9037130
DOI: 10.1530/eje.0.1360074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9037130-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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