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Article

CYP2C19- and CYP3A4-dependent omeprazole metabolism in West Mexicans.

Journal of clinical pharmacology - 1 Nov 2003

Gonzalez Héctor M, Romero Elba M, Peregrina A Aaron, de J Chávez Teresa, Escobar-Islas Estanislao, Lozano Felipe, Hoyo-Vadillo Carlos

Abstract excerpt

Omeprazole has been used as a drug probe for CYP2C19, but no systematic data are available for Mexican populations. The aim of this study was to evaluate the phenotype frequencies of the CYP2C19 polymorphism in West Mexicans. Besides omeprazole, sulfone was measured to evaluate CYP3A4 after administration of the 20-mg dose to 127 healthy volunteers. Logarithms of metabolic indexes of omeprazole/hydroxyomeprazole...

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Identifiers

PMID: 14551175
DOI: 10.1177/0091270003258170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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