Phenotyping of CYP2C19 with enantiospecific HPLC-quantification of R- and S-mephenytoin and comparison with the intron4/exon5 G-->A-splice site mutation.

doi:10.1097/00008571-199504000-00004

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Article

Phenotyping of CYP2C19 with enantiospecific HPLC-quantification of R- and S-mephenytoin and comparison with the intron4/exon5 G-->A-splice site mutation.

Pharmacogenetics - 1 Apr 1995

Brockmöller J, Rost K L, Gross D, Schenkel A, Roots I

Abstract excerpt

S-Mephenytoin 4'-hydroxylase (CYP2C19) is a genetically polymorphic cytochrome P450. A modified method for CYP2C19 phenotyping was evaluated in 174 healthy German volunteers and the results were compared with genotyping for the intron4/exon5 G-->A splice site mutation (m1) of CYP2C19, associated...

Topics

Adenine
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Amino Acid Sequence
Arginine
Aryl Hydrocarbon Hydroxylases
Base Sequence
Body Weight
Chromatography, High Pressure Liquid
Cysteine
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
DNA Primers
Exons
Female

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Open in PubMed

Identifiers

PMID: 7663532
DOI: 10.1097/00008571-199504000-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7663532-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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