Interphenotype differences in disposition and effect on gastrin levels of omeprazole--suitability of omeprazole as a probe for CYP2C19.

doi:10.1111/j.1365-2125.1995.tb04488.x

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Article

Interphenotype differences in disposition and effect on gastrin levels of omeprazole--suitability of omeprazole as a probe for CYP2C19.

British journal of clinical pharmacology - 1 May 1995

Chang M, Tybring G, Dahl M L, Götharson E, Sagar M, Seensalu R, Bertilsson L

Abstract excerpt

1. Fourteen healthy Swedish Caucasian subjects were given 20 mg of omeprazole orally each morning for 8 days. The subjects included five poor metabolisers (PM) of S-mephenytoin, four heterozygous extensive metabolisers (hetEM) and five subjects with a very rapid metabolism (rapidEM). 2. After the...

Topics

2-Pyridinylmethylsulfinylbenzimidazoles
Administration, Oral
Adult
Aryl Hydrocarbon Hydroxylases
Chromatography, High Pressure Liquid
Cohort Studies
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
Female
Gastrins
Heterozygote
Humans
Male
Mixed Function Oxygenases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Omeprazole

Phenotype

Polymorphism, Genetic

Sweden

Source

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Identifiers

PMID: 7669487
DOI: 10.1111/j.1365-2125.1995.tb04488.x
PMCID: PMC1365058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7669487-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.