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Article

Establishing genetic interactions by a synthetic dosage lethality phenotype.

Genetics - 1 May 1996

Kroll E S, Hyland K M, Hieter P, Li J J

Abstract excerpt

We have devised a genetic screen, termed synthetic dosage lethality, in which a cloned "reference" gene is inducibly overexpressed in a set of mutant strains carrying potential "target" mutations. To test the specificity of the method, two reference genes, CTF13, encoding a centromere binding protein, and ORC6, encoding a subunit of the origin of replication binding complex, were overexpressed in a large...

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Source

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Identifiers

PMID: 8722765
DOI: 10.1093/genetics/143.1.95
PMCID: PMC1207298

Genes

ORC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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