Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.

doi:10.1073/pnas.0503504102

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Article

Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2005

Measday Vivien, Baetz Kristin, Guzzo Julie, Yuen Karen, Kwok Teresa, Sheikh Bilal, Ding Huiming, Ueta Ryo, Hoac Trinh, Cheng Benjamin, Pot Isabelle, Tong Amy, Yamaguchi-Iwai Yuko, Boone Charles, Hieter Phil, Andrews Brenda

Abstract excerpt

Accurate chromosome segregation requires the execution and coordination of many processes during mitosis, including DNA replication, sister chromatid cohesion, and attachment of chromosomes to spindle microtubules via the kinetochore complex. Additional pathways are likely involved because faithful chromosome segregation also requires proteins that are not physically associated with the chromosome. Using...

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PMID: 16172405
DOI: 10.1073/pnas.0503504102
PMCID: PMC1236538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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