Article
Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell.
Nature biotechnology - 15 May 2011
Magtanong Leslie, Ho Cheuk Hei, Barker Sarah L, Jiao Wei, Baryshnikova Anastasia, Bahr Sondra, Smith Andrew M, Heisler Lawrence E, Choy John S, Kuzmin Elena, Andrusiak Kerry, Kobylianski Anna, Li Zhijian, Costanzo Michael, Basrai Munira A, Giaever Guri, Nislow Corey, Andrews Brenda, Boone Charles
Abstract excerpt
Dosage suppression is a genetic interaction in which overproduction of one gene rescues a mutant phenotype of another gene. Although dosage suppression is known to map functional connections among genes, the extent to which it might illuminate global cellular functions is unclear. Here we analyze a network of interactions linking dosage suppressors to 437 essential genes in yeast. For 424 genes, we curated...
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