Article
Mammalian cells resistant to tumor suppressor genes.
Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 1996
Pietenpol J A, Lengauer C, Jordan J, Kinzler K W, Vogelstein B
Abstract excerpt
Expression of p53 causes growth arrest or apoptosis in many normal and neoplastic cell types, but the relationship between these two effects has remained obscure. To begin to dissect the underlying mechanisms at a genetic level, we have generated mutant cells resistant to the action of wild-type...
Topics
- Adenovirus E1A Proteins
- Animals
- Apoptosis
- Cell Cycle
- Cell Line
- Cell Transformation, Neoplastic
- DNA Damage
- Genes, Dominant
- Genes, Tumor Suppressor
- Mutation
- Rats
- Retinoblastoma Protein