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Article

Mammalian cells resistant to tumor suppressor genes.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 1996

Pietenpol J A, Lengauer C, Jordan J, Kinzler K W, Vogelstein B

Abstract excerpt

Expression of p53 causes growth arrest or apoptosis in many normal and neoplastic cell types, but the relationship between these two effects has remained obscure. To begin to dissect the underlying mechanisms at a genetic level, we have generated mutant cells resistant to the action of wild-type p53. Rat embryo fibroblasts transformed with ras and a temperature-sensitive p53 (tsp53(135val)) gene were chemically...

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Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genes, Tumor Suppressor

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 8710881
DOI: 10.1073/pnas.93.16.8390
PMCID: PMC38681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mammalian cells resistant to tumor suppressor genes.PMID 8710881Read ↗

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